Current Issue : April - June Volume : 2018 Issue Number : 2 Articles : 5 Articles
Obesity is a well-known factor that leads to many diseases including endometrial cancer. The adipose tissue is a heterogeneous\norgan of internal secretion. Visfatin is a newly discovered protein produced by fat tissues.The purpose of this work was to evaluate\nserum level concentrations of visfatin in patients with endometrial cancer based on clinical progression and histopathological\ntumor differentiation.The diagnostic capabilities of visfatin protein in high differentiation (FIGO III and IV) from a lower (FIGO\nI and II) clinical stage and prognostic degree of cell differentiation (G1 versus G2, G2 versus G3) on the basis of the analysis of the\narea under the ROC curve are as follows: 0.87, 0.81, and 0.86. Significantly higher concentrations of visfatin have been observed in\npatients with invasion of the blood vessels (...
Background. Serum bilirubin is a potent endogenous antioxidant with anti-inflammatory properties. Several cross-sectional studies\nhave reported that bilirubin was negatively associated with metabolic syndrome. However, in recent longitudinal studies, the\nrelations between bilirubin and metabolic syndrome are inconsistent. Moreover, previous studies mainly focused on serum total\nbilirubin which is the sum of direct bilirubin and indirect bilirubin. For these reasons, the longitudinal effect of bilirubin subtypes\non incident metabolic syndrome was evaluated in Chinese men. Methods. The study cohort involved 1339 Chinese men without\nmetabolic syndrome. Metabolic syndrome was defined by the American Heart Association/National Heart, Lung and Blood\nInstitute (AHA/NHLBI) criteria, using BMI for the replacement of waist circumference. Results.There are 117 incident metabolic\nsyndrome cases (8.7%) during 5 years of follow-up among 1339 metabolic syndrome-free participants at baseline. After adjusting\nfor age, drinking, smoking, physical activity, TG, and LDL-C, the odd ratios (ORs) and 95% confidence intervals (CIs) for MetS\nincidence in the second, third, and fourth quartiles versus the first quartile of DBil concentration were 1.00 (0.61ââ?¬â??1.63), 0.57\n(0.32ââ?¬â??1.02), and 0.51 (0.28ââ?¬â??0.92) (...
The incidence of diabetes has been gradually increasing, not only in middle-aged individuals but also in young individuals.\nHowever, insulin and glucose patterns have not been investigated in apparently healthy young individuals, as they are typically\ngrouped as controls. In this study, we investigated and classified glucose and insulin patterns in healthy young women. Sixtytwo\nnonobese women without metabolic disease were recruited. The subjects underwent a 75 g oral glucose tolerance test\n(OGTT), physical measurements, and a biochemical examination. Two subjects displayed impaired glucose tolerance. The 62\nsubjects were categorized into four patterns by plasma glucose and insulin peak time during OGTT: normal type (n = 39),\ninsulin-late type (n = 11), insulin- and glucose-late type (n = 7), and insulin-very late type (n = 5). OGTT glucose and insulin\nlevels at all time points, insulinogenic index, HOMA-IR, and glucose area under the curve (AUC) significantly differed among\nthe four groups. However, insulin AUC did not significantly differ. We did not detect significant differences in body condition\nor biochemical measurements. Our study demonstrated that some healthy young individuals might have delayed insulin\nsecretion by OGTT. Early detection of altered glucose metabolism might be helpful to improve lifestyle choices and prevent\nprogression to diabetes....
Ardisia japonica is a well-known traditional Chinese medicinal herb used as a diuretic, for treating cough and for stopping uterine\nbleeding. A simple, sensitive, and reliable LC-MS/MS method was developed to determine six active compounds in rat plasma and\nthis method was further applied to the pharmacokinetic study of these compounds after oral administration of Ardisia japonica\nextract. Acetonitrile was used to precipitate the protein in the plasma samples. Using acetonitrile and formic acid aqueous solution\n(0.05%) as themobile phase, the separation of the six compounds and internal standards was achieved at a flow rate of 300 ...
Nucleic acid oxidation plays an important role in the pathophysiology progress of a variety of diseases. 8-oxo-7,8-dihydro-\n2�-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), which originate from DNA and RNA\noxidation, were the most widely used indicators for oxidative stress. The study investigated the relation between 8-oxodGsn,\n8-oxo-Gsn, and CKD. 146 patients with CKD were divided into five disease stages, and their fasting blood and\nmorning urine were collected. The levels of 8-oxo-dGsn and 8-oxo-Gsn in plasma and urine were quantified by LCMS/\nMS. The ratio of urinary 8-oxo-Gsn to creatinine increased from stages 1 to 4 corresponding to the increased\nseverity of CKD, but it decreased in stage 5. And plasma 8-oxo-Gsn gradually increased with the decline of renal\nfunction. In particular, the increased ratio of plasma and urine 8-oxo-Gsn in stage 5 exceeded the concentration of\ncreatinine. This trend was similar to the estimated glomerular filtration rate (eGFR), which indicates that 8-oxo-Gsn\ncould be an appropriate indicator for renal function. Our finding indicates that as the disease progresses, RNA oxidation\nis increased. The significant increase in the ratio of plasma and urinary 8-oxo-Gsn is a novel evaluation index of end-stage\nrenal disease....
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